C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/81 (2006.01) A61K 31/337 (2006.01) A61K 38/10 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01)
Patent
CA 2688344
Based on our identification of a polypeptide (Angiopep-7) that is efficiently transported to cells such as liver, lung, kidney, spleen, and muscle, the invention provides polypeptides, conjugates including the polypeptides, and methods for treating diseases associated with these cell types. Unlike other aprotinin related polypeptides identified herein (including Angiopep-3, Angiopep-4a Angiopep-4b Angiopep-5, and Angiopep-6) which efficiently cross the blood-brain barrier (BBB), Angiopep-7 is not efficiently transported across the BBB.
Sur la base de notre identification d'un polypeptide (Angiopep-7) qui est efficacement transporté vers des cellules telles que le foie, le poumon, le rein, la rate et le muscle, l'invention concerne des polypeptides, des conjugués comprenant les polypeptides, et des procédés pour traiter des maladies associées à ces types de cellules. A la différence d'autres polypeptides apparentés à l'aprotinine identifiés présentement (comprenant Angiopep-3, Angiopep-4a, Angiopep-4b, Angiopep-5 et Angiopep-6) qui traversent de manière effective la barrière sang-cerveau (BBB), l'Angiopep-7 n'est pas transporté de manière effective à travers la BBB.
Beliveau Richard
Che Christian
Demeule Michel
Regina Anthony
Angiochem Inc.
Goudreau Gage Dubuc
Universite Du Quebec A. Montreal
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