Aptamers comprising arabinose modified nucleotides

Details Aptamers comprising arabinose modified nucleotides Aptamers comprising arabinose modified nucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 31/7088 (2006.01) A61K 31/712 (2006.01) A61K 48/00 (2006.01) A61P 7/02 (2006.01) A61P 31/18 (2006.01) A61P 35/00 (2006.01) C07H 21/02 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2623818

Nucleic acid ligands (or aptamers) that form a G-tetrad containing at least one arabinose modified nucleotide are provided. Preferably, the arabinose modified nucleotide is 2'-deoxy-2'-fluoroarabinonucleotide (FANA) nucleotide.

L'invention concerne des ligands d'acide nucléique (aptamères) qui forment un G-tétrade contenant au moins un nucléotide modifié par arabinose. De préférence, le nucléotide modifié par arabinose est un nucléotide 2'-désoxy-2'-fluoroarabinonucléotide (FANA).

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