Aptamers that bind to prion protein

Details Aptamers that bind to prion protein Aptamers that bind to prion protein

C - Chemistry, Metallurgy

12

N

C12N 15/115 (2010.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) G01N 33/68 (2006.01) C07H 21/00 (2006.01) C40B 40/06 (2006.01)

Patent

CA 2612401

Compositions are provided in the form of nucleotide aptamerss that are capapble of binding PrP, and in some embodiments, differentially binding PrP isoforms. Also provided are methods for identifying PrP in a sample, and in some embodiments, either selectively removing PrP or PrP isoforms from a sample, or inactivating them within a sample.

L'invention concerne des compositions ayant la forme d'aptamères de nucléotides capables de se lier à PrP, et dans certains modes de réalisation, de se lier de façon différentielle aux isoformes PrP. L'invention concerne aussi des procédés pour identifier PrP dans un échantillon, et dans certains modes de réalisation, soit évacuer sélectivement les isoformes PrP ou PrP d'un échantillon soit les inactiver dans un échantillon.

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