C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) C07K 14/54 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2557633
The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics.
La présente invention a trait à des substances et des procédés de traitement de maladies immunitaires dans lesquelles des cytokines sont impliquées dans la pathogenèse. Les substances et les procédés de la présente invention sont utiles dans le traitement de maladies auto-immunes. Les substances et les procédés de la présente invention sont dirigés vers des ligands d'acides nucléiques capables de liaison à des cytokines d'IL-23 humaine et/ou d'IL-12 humaine et sont donc modulateurs de leur activité biologique et utiles comme agents thérapeutiques dans des traitements immunitaires, auto-immuns et de cancer.
Diener John L.
Ferguson Alicia
Hamaguchi Nobuko
Keene Sara Chesworth
Lagasse H. A. Daniel
Archemix Corp.
Mbm Intellectual Property Law Llp
LandOfFree
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