Aqueous agent

Details Aqueous agent Aqueous agent

A - Human Necessities

61

K

A61K 47/40 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 31/47 (2006.01) A61K 47/22 (2006.01)

Patent

CA 2121723

ABSTRACT OF THE DISCLOSURE An aqueous agent comprising at least one arginine amide selected from the group consisting of (2R,4R)-4-methyl-1-[N2- ((RS)-3-methyl-1,2,3,4-tetrahydro-8-quinolinesulfonyl)-L- arginyl]-2-piperidinecarboxylic acid, monohydrate thereof and pharmacologically acceptable salts thereof, and at least one compound selected from the group consisting of cyclodextrin and caffeine; a method for improving the solubility of arginine amide in water, comprising adding at least one compound selected from the group consisting of cyclodextrin and caffeine; and a method for stabilizing arginine amide in water, comprising adding caffeine. According to the present invention, the solubility of arginine amide in water can be enhanced to, for example, a concentration permitting inhibition of fibrin formation at the time of entoptic operation. In addition, the stability of arginine amide in water can be enhanced with less irritation of the eye.

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