Aqueous compositions containing corticosteroids for nasal...

A - Human Necessities – 61 – K

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Details

A61K 31/56 (2006.01) A61K 9/19 (2006.01) A61K 31/569 (2006.01) A61K 31/573 (2006.01) A61K 31/58 (2006.01) A61K 47/22 (2006.01) A61K 47/44 (2006.01)

Patent

CA 2335900

The present invention provides compositions containing corticosteroid compounds as active agents for the treatment of ailments and diseases of the respiratory tract, particularly the lungs, by way of nasal and pulmonary administration. The corticosteroid compounds are present in a dissolved state in the compositions. The compositions can be formulated in a concentrated, essentially non-aqueous form for storage or in a diluted, aqueous-based form for ready delivery. In a preferred embodiment, the corticosteroid composition contains an ethoxylated derivative of vitamin E and/or a polyethylene glycol fatty acid ester as the high-HLB surfactant present in the formulation. The compositions are ideally suited for inhaled delivery with a nebulizer or for nasal delivery.

L'invention concerne des compositions contenant comme principes actifs des composés à base de corticostéroïdes, qui sont destinées au traitement des troubles et des maladies des voies respiratoires, notamment des poumons, par administration nasale ou pulmonaire. Les composés à base de corticostéroïdes sont présents à l'état dissous dans les compositions. Celles-ci peuvent être formulées soit sous forme concentrée, sensiblement non aqueuse, en vue du stockage, soit sous forme diluée, aqueuse, prête à l'emploi. Dans un mode de réalisation préféré, la composition de corticostéroïdes contient un dérivé éthoxylé de la vitamine E et/ou un ester d'acide gras et de polyéthylène glycol, qui, dans la formulation, constitue le seul tensioactif ayant un rapport hydrophile-lipophile (HLB) élevé. Ces compositions sont idéales pour l'administration pulmonaire au moyen d'un nébuliseur et pour l'administration nasale.

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