A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/40 (2006.01) A61K 9/08 (2006.01) A61K 9/10 (2006.01) A61K 31/4164 (2006.01) A61K 47/10 (2006.01) A61K 47/22 (2006.01) A61K 47/38 (2006.01) A61P 9/00 (2006.01) C08J 3/075 (2006.01) C08K 5/3432 (2006.01) C08K 5/3445 (2006.01) C08L 5/16 (2006.01)
Patent
CA 2470492
An aqueous solution of metronidazole in which the concentration of metronidazole is higher than 0.75%. The solution contains a combination of solubility-enhancing agents, one of which is a cyclodextrin such as beta- cyclodextrin and the second is a compound other than a cyclodextrin. Methods of manufacture and therapeutic use of the solution are disclosed.
L'invention concerne une solution aqueuse de métronidazole dans laquelle la teneur en métronidazole est supérieure à 0,75 %. La solution renferme une combinaison d'agents d'amélioration de la solubilité, dont un est une cyclodextrine, notamment une betacyclodextrine et dont l'autre est un composé autre qu'une cyclodextrine. Font également l'objet de cette invention les procédés de préparation de ladite solution et son utilisation thérapeutique.
Chang Yunik
Dow Gordon J.
Dow Pharmaceutical Sciences
Oyen Wiggs Green & Mutala Llp
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