Aqueous ecabet sodium solution preparation

Details Aqueous ecabet sodium solution preparation Aqueous ecabet sodium solution preparation

A - Human Necessities

61

K

A61K 31/192 (2006.01) A61K 9/08 (2006.01) A61K 47/02 (2006.01) A61K 47/14 (2006.01) A61P 1/00 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2460167

An aqueous ecabet sodium solution preparation which contains sulfodehydroabietic acid and a salt/ion thereof in an amount of 1 w/v% or larger in terms of ecabet sodium and further contains at least one pH buffer selected among polycarboxylic acid salts and polyphosphoric acid salts and an inorganic base so as to have a pH regulated to 7 to 8.5. It is stable and less irritative and is suitable for use in intestinal injections.

La présente invention concerne une préparation de solution de sodium ecabet qui contient de l'acide sulfodéhydroabiétique et un sel/ion de celui-ci, avec une quantité supérieure ou égale à 1% poids/vol de sodium ecabet, et qui contient également au moins une solution tampon pour pH choisie parmi des sels d'acide polycarboxylique et des sels d'acide polyphosphorique, ainsi qu'une base inorganique, de façon à présenter un pH allant de 7 à 8,5. Cette préparation est stable, moins irritante que les préparations connues et adaptée aux injections intestinales.

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