Aqueous ifosfamide composition

A - Human Necessities – 61 – K

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Details

A61K 31/535 (2006.01) A61K 31/675 (2006.01) A61K 47/02 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2470472

ABSTRACTThis invention is directed towards a ready-to-use aqueous composition of ifosfamide. In one embodiment, the invention is directed to an aqueous ifosfamide composition which comprises ifosfamide, a pharmaceutically acceptable buffer, and water. The concentration of ifosfamide in the composition may be between about 40 mM and about 400 mM. The concentration of buffer in the composition may be between about 10 mM and about 260 mM. The molar ratio of ifosfamide to buffer may be between about 0.5:1 to about 20:1. The pH of the composition may be between about 4 and about 8.

Cette invention concerne un composition aqueuse d'ifosfamide prête à l'emploi. Dans un mode de réalisation, l'invention concerne une composition ifosfamide aqueuse comprenant un ifosfamide, un tampon acceptable au plan pharmaceutique et de l'eau. La concentration d'ifosfamide dans la composition peut se situer entre 40 mM et 400 environ, celle du tampon dans la composition entre 10 mM et 260 mM environ. Le rapport molaire entre l'ifosfamide et le tampon peut être compris entre 0,5:1 et 20:1 environ. Le pH de la composition peut être compris entre 4 et 8 environ.

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