Aqueous intraocular penetration-promoting eye drop

Details Aqueous intraocular penetration-promoting eye drop Aqueous intraocular penetration-promoting eye drop

A - Human Necessities

61

K

A61K 31/196 (2006.01) A61K 31/133 (2006.01) A61K 31/185 (2006.01) A61P 27/02 (2006.01) A61P 27/14 (2006.01) A61P 37/02 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2560559

Aqueous eye drops which contain 2-amino-3-(4-bromobenzoyl)phenylacetic acid, a pharmacologically acceptable salt thereof, or a hydrate of either and an organic amine (e.g., aminoethylsulfonic acid or trometamol) or a salt thereof. When applied once a day, the eye drops enable the 2-amino-3-(4- bromobenzoyl)phenylacetic acid to be present in the aqueous humor over at least 24 hours in a remedially effective concentration. It is hence useful as aqueous eye drops of the one-administration-a-day type for the treatment of inflammatory diseases on the external segment or anterior segment of the eye.

L'invention concerne des gouttes ophtalmiques aqueuses contenant l'acide 2-amino-3-(4-bromobenzoyl)phénylacétique, un sel pharmacologiquement acceptable de celui-ci, ou un hydrate de l'un de ceux-ci, ainsi qu'une amine organique (p.ex. de l'acide aminoéthylsulfonique ou du trométamol) ou un sel de celle-ci. Lors d'une application quotidienne unique, les gouttes ophtalmiques permettent à l'acide 2-amino-3-(4-bromobenzoyl)phénylacétique d'être présent dans l'humeur aqueuse pendant au moins 24 heures à une concentration efficace sur le plan curatif. Dès lors, ces gouttes sont utiles en tant que gouttes ophtalmiques aqueuses à administrer une fois par jour pour le traitement des maladies inflammatoires du segment externe ou du segment antérieur de l'oel.

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