Aqueous liquid pharmaceutical composition

Details Aqueous liquid pharmaceutical composition Aqueous liquid pharmaceutical composition

A - Human Necessities

61

K

A61K 31/496 (2006.01) A61K 9/08 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2307632

There is provided an aqueous liquid pharmaceutical composition which comprises Gatifloxacin (chemical nomenclature: (~)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl- 1-piperazinyl)-4-oxo-3-quinoline carboxylic acid) or its salt and disodium edetate. Further, there are provided a method for raising corneal permeability of Gatifloxacin, a method for preventing precipitation of Gatifloxacin crystals, and a method for preventing coloration of Gatifloxacin by incorporating disodium edetate into an aqueous liquid preparation containing Gatifloxacin or its salt.

L'invention porte sur des préparations liquides aqueuses contenant une gatifloxacine (nom chimique: acide (+/-)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-méthoxy-7-(3-méthyl-1-piperazinyl)-4-oxo-quinolinecarboxylique) ou son sel et un édétate de sodium. L'invention porte également sur un procédé visant à renforcer la perméabilité cornéenne de la gatifloxacine, sur un procédé visant à prévenir la cristallisation de la gatifloxacine et sur un procédé visant à prévenir la coloration de la gatifloxacine, tout cela en mélangeant la gatifloxacine ou son sel avec l'édétate de sodium.

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