Aqueous liquid preparation containing amide compound

A - Human Necessities – 61 – K

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Details

A61K 31/437 (2006.01) A61K 9/08 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/36 (2006.01) A61P 27/06 (2006.01) A61P 43/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2659687

It is intended to provide an aqueous liquid preparation which promotes the migration of a compound having an Rho kinase inhibitory activity toward a topical site and can sustain a definite drug concentration even in the case of decreasing the dosing frequency. This problem can be solved by an aqueous liquid preparation which contains a compound represented by the following general formula (I): (I) wherein each symbol has the meaning as defined in the description; an isomer thereof and/or a pharmaceutically acceptable acid addition salt of the same together with an ion-pair agent or a water-soluble polymer.

La présente invention porte sur une préparation liquide aqueuse qui favorise la migration d'un composé inhibiteur de Rho-kinase vers un site local, et qui peut maintenir une concentration en médicament donnée même en cas de diminution de la fréquence d'administration. Ce problème peut être résolu en employant une préparation liquide aqueuse contenant un composé de formule générale (I) suivante : (I) où chaque symbole a la définition donnée dans la description ; l'un de ses isomères et/ou sels d'addition acide de qualité pharmaceutique, avec un agent ionique ou un polymère hydrosoluble.

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