Aqueous ophthalmic solutions and method for preserving same

Details Aqueous ophthalmic solutions and method for preserving same Aqueous ophthalmic solutions and method for preserving same

A - Human Necessities

61

K

167/292, 167/322

A61K 47/02 (2006.01) A01N 59/00 (2006.01) A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61L 2/18 (2006.01) A61L 12/10 (2006.01) G02C 13/00 (2006.01)

Patent

CA 2003198

Stabilized chlorine dioxide is a preservative for ophthalmic formulations. The stabilized chlorine dioxide, when employed as a preservative or in the formulation of aqueous saline ophthalmic solutions is present in an amount of from about 0.0002 to about 0.02 weight/volume percent. The aqueous saline ophthalmic solutions, in addition to the stabilized chlorine dioxide and the water which functions as a vehicle for the solutions, contains from about 0.5 to about 0.9 weight/volume percent of an ophthalmically acceptable inorganic salt and an effective minor amount of a buffering agent to stabilize the ophthalmic solution with an acceptable physiological pH. A method for preserving aqueous saline ophthalmic solutions utilizing stabilized chlorine dioxide is also set forth.

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