Aqueous process for manufacturing paroxetine solid dispersions

Details Aqueous process for manufacturing paroxetine solid dispersions Aqueous process for manufacturing paroxetine solid dispersions

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 31/4525 (2006.01)

Patent

CA 2331288

A process for preparing solid, amorphous paroxetine comprising: (A) mixing paroxetine free base or a pharmaceutically acceptable paroxetine salt with water and pharmaceutically acceptable polymer; and (B) drying to form a composition comprising amorphous paroxetine and polymer, eliminating the need for organic solvents common for the solvent process. The resultant amorphous solid paroxetine composition is free from the crystalline form, and yet has good handling properties, making it suitable for pharmaceutical use in the traditional tablet dosage form.

L'invention concerne un procédé permettant de préparer de la paroxétine amorphe solide consistant: (A) à mélanger une base exempte de paroxétine ou un sel de paroxétine pharmaceutiquement acceptable avec de l'eau et un polymère pharmaceutiquement acceptable; et (B) à laisser sécher de manière à former une composition renfermant de la paroxétine amorphe et un polymère, éliminant ainsi la nécessité d'utiliser des solvants organiques communs pour ce genre de procédé au solvant. La composition de paroxétine solide amorphe obtenue est exempte de toute forme cristalline, mais elle présente quand même de bonnes propriétés de manipulation, ce qui en fait une composition appropriée pour un usage pharmaceutique sous la forme posologique classique de comprimés.

Affiliated with

Also associated with

Rating

Aqueous process for manufacturing paroxetine solid dispersions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aqueous process for manufacturing paroxetine solid dispersions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aqueous process for manufacturing paroxetine solid dispersions will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1989308