Aqueous prolonged release formulations of somatotropin

A - Human Necessities – 61 – K

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A61K 38/27 (2006.01) A61K 9/08 (2006.01)

Patent

CA 2178610

Prolonged parenteral release into the circulatory system of a cow of a bioactive bovine somatotropin at desirably effective levels can be achieved using novel compositions in which the bovine somatotropin is present in an aqueous liquid at a dose of at least about 150 mg and at a concentration of at least about 50 mg/ml. The aqueous bovine somatotropin formulation provides for the sustained release of bovine somatotropin into the circulatory system of the animal for greater than three (3) days.

On peut effectuer la libération parentérale prolongée, dans le système circulatoire d'une vache, d'une somatotropine bovine bioactive à des taux efficaces désirés, en utilisant de nouvelles compositions dans lesquelles la somatotropine bovine est présente dans un liquide aqueux à une dose d'au moins environ 150 mg et une concentration d'au moins environ 50 mg/ml. La formulation aqueuse de somatotropine bovine assure la libération prolongée de somatotropine bovine dans le système circulatoire de l'animal pendant une durée supérieure à trois (3) jours.

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