Aqueous steroid formulations for nasal administration

Details Aqueous steroid formulations for nasal administration Aqueous steroid formulations for nasal administration

A - Human Necessities

61

K

167/192

A61K 31/57 (2006.01) A61K 9/00 (2006.01) A61K 31/58 (2006.01)

Patent

CA 1288048

25560-FF ABSTRACT OF THE DISCLOSURE A non-stinging aqueous anti-inflammatory steroid formulation suitable for intranasal administration comprises: an anti-inflammatory steroid in an amount between about 0.01% and about 0.05% (w/v); propylene glycol in an amount between about 2% and about 10% (w/v); PEG 400 in an amount between about 10% and about 25% (w/v); polysorbate 20 in an amount between about 1% and about 4% (w/v); an effective amount of a preservative; an effective amount of a stabilizer; an effective amount of an antioxidant; water; and pH buffering agent sufficient to adjust the pH of the resulting solution to between about 3.5 and about 7.

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