C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/477, 260/514
C07C 31/00 (2006.01) C07C 29/147 (2006.01) C07C 29/60 (2006.01) C07C 43/295 (2006.01) C07C 57/58 (2006.01) C07C 57/60 (2006.01) C07C 57/76 (2006.01) C07C 59/56 (2006.01) C07C 59/68 (2006.01) C07C 69/76 (2006.01) C07F 1/00 (2006.01) C07F 9/40 (2006.01)
Patent
CA 1086770
ABSTRACT OF THE DISCLOSURE Compounds of the formula Image wherein R1 and R2 are the same or different and are F, Cl or Br; Q is -CH(CH3)-CH2-, -C(OH)(CH3)-CH2- or -C(CH3)=CH-; Y is COOH, COOR3, CH2OH or CH2OAc; n is 0 or 1; R3 is alkyl, aryl of up to 8 carbon atoms or C6H4NHCOCH3; and Ac is alkanoyl of 1 - 8 carbon atoms; and physiologi- cally acceptable salts thereof, are anti-inflammatory agents. Such com- pounds can be made from compounds of the formula Z - X, wherein Z is Image , wherein X is CE(CH3)-CH2Y, CE(CH3)-CH[P=O(OR4)2], -CH(CH3)-C(=PAr3)-Y, CH(CH3)-CH(CO-R4)-Y or -QW wherein E is Hal, Hal being Cl, Br or I, or a functionally-modified hydroxyl group selected from an alcoholate and an acylate, R4 is alkyl of 1 - 12 carbon atoms, aryl of 6 - 12 carbon atoms, or aralkyl of 7 - 12 carbon atoms, and W is functionally-modified COOH group selected from an ester, a nitrile, an iminoether and an amide, or a functionally-modified CH2OH selected from an alcoholate and an acylate which differs from Y, and R1, R2, n, Y, and Q are as defined above, and X can thus be converted to -Q-Y, where Q and Y are as defined above. The compounds also have analgesic and antipyretic effects, lowering of the liquid level, i.e., chlolesterol and triglyceride level and inhibiting thrombocyte aggregation.
255752
Gante Joachim
Kurmeier Hans-Adolf
Orth Dieter
Schacht Erich
Wild Albrecht
Marcus & Associates
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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