Aralkyl-1,2-diamines having calcimimetic activity and...

C - Chemistry – Metallurgy – 07 – C

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Details

C07C 311/18 (2006.01) A61K 31/135 (2006.01) A61K 31/18 (2006.01) C07C 211/27 (2006.01) C07C 211/30 (2006.01) C07C 311/29 (2006.01) C07D 333/34 (2006.01)

Patent

CA 2390880

The invention concerns compounds of general formula (I) wherein: X represents a SO¿2? or CH¿2? group; R1 represents a hydrogen or halogen atom or an alkoxy, aryl aralkyl group or an alkyl group substituted or not with one or several halogen atoms, n is equal to 0, 1 or 2, and R2 represents a hydrogen or halogen atom or an alkyl or alkoxy group, and their salt with a pharmaceutically acceptable acid. The invention also concerns the method for preparing said compounds, pharmaceutical compositions containing them and their use as modulator of CaSR activity and as medicine particularly designed for treating diseases or physiological disorders involving modulation of CaSR activity.

La présente invention concerne donc les composés de formule générale (I) dans laquelle: le groupe X représente un groupe SO2 ou CH2; le groupe R1 représente un atome d'hydrogène ou d'halogène ou un groupe alkoxy, aryle, aralkyle ou un groupe alkyle substitué ou non par un ou plusieurs atomes d'halogènes; n est égale à 0, 1 ou 2, et le groupe R2 représente un atome d'hydrogène ou d'halogène ou un groupe alkyle ou alkoxy, et leur sel avec un acide pharmaceutiquement acceptable. Elle concerne également leur préparation, les compositions pharmaceutiques les comprenant et leur utilisation comme modulateur de l'activité CaSR et comme médicament destiné de préférence au traitement des maladies ou des désordres physiologiques faisant intervenir la modulation de l'activité des CaSR.

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