C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/179, 260/250
C07D 215/36 (2006.01) C07D 209/30 (2006.01) C07D 213/70 (2006.01) C07D 213/71 (2006.01) C07D 235/22 (2006.01) C07D 261/10 (2006.01) C07D 277/36 (2006.01) C07D 307/64 (2006.01) C07D 307/82 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01)
Patent
CA 1335379
Disclosed are new aminoalkoxyphenyl derivatives of formula: Image (1) in which B is -S-, -SO- or -SO2; R1 and R2 are hydrogen, methyl, ethyl or halogen; A is alkylene 2-hydroxypropylene; R3 is hydrogen or alkyl ; R4 is pyridyl, phenyl, 2,3- methylenedioxyphenyl or 3,4-methylenedioxyphenyl; Alk is a single bond or an alkylene; Cy represents a group of formula : Image or Image or (D) (E) Image or Image or (F) (G) Image (H) in which R is hydrogen, alkyl, cycloalkyl, benzyl or phenyl; R5 and R6 together with the carbon atom to which they are attached forms mono- or di-cyclic carboxylic group; an aromatic 5-membered heterocyclic group or a 6- to 10- membered mono- or di-cyclic heterocyclic group; R7 and R8 each are hydrogen, alkyl or phenyl or together represent a 6-membered carbocyclic ring; R9 is O or Si;R10 is O, S or - N-R11; R12 and R13, each are hydrogen, alkyl or benzol, with the proviso that Cy does not represent a l-indolizinyl group, as well as their N-oxide derivatives and their pharmaceutically acceptable salts. These derivatives are particularly are useful for the treatment of angina pectoris, hypertension, arrythmia and cerebral circulatory insufficiency. They are also useful as potentiators of anti- cancer drugs.
574002
Chatelain Pierre
Gubin Jean
Inion Henri
Lucchetti Jean
Mahaux Jean-Marie
Robic
Sanofi
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