Aralykyl (arylethynyl) aralkyl amines and their use as...

Details Aralykyl (arylethynyl) aralkyl amines and their use as... Aralykyl (arylethynyl) aralkyl amines and their use as...

C - Chemistry, Metallurgy

07

C

167/179, 260/602

C07C 217/56 (2006.01) A61K 31/135 (2006.01) C07C 45/58 (2006.01) C07C 45/62 (2006.01) C07C 45/63 (2006.01) C07C 45/68 (2006.01) C07C 45/74 (2006.01) C07C 49/223 (2006.01) C07C 49/255 (2006.01) C07C 59/64 (2006.01) C07C 217/62 (2006.01) C07C 323/29 (2006.01) C07D 303/40 (2006.01) C07F 1/08 (2006.01)

Patent

CA 1301183

ARALKYL (ARYLETHYNYL)ARALKYL AMINES AND THEIR USE AS VASODILATORS AND ANTIHYPERTENSIVES ABSTRACT Acetylenes of the formula (I): Image (I) wherein Y, m, R1, R2, q, Alk, R3, n and R4 are as defined herein and Ar1 and Ar2 are aromatic, including the salts and ammonium derivatives of formula (I), in treating angina, hypertension and cardiac arrhythmias. Pharmaceutical compositions, methods of use and synthesis and novel intermediates are also part of the invention. One such novel intermediate is represented by the formula Image (IV) wherein Y, m, R1, R2, R3, R4, X, n, Alk, q and Ar2 are as defined herein.

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