Archaeal polar lipid aggregates for administration to animals

Details Archaeal polar lipid aggregates for administration to animals Archaeal polar lipid aggregates for administration to animals

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 9/00 (2006.01) A61K 35/66 (2006.01) A61K 39/00 (2006.01) A61P 31/00 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2672338

The invention provides non-replicating compositions, and methods for the delivery of these compositions containing pharmaceuticals, biologically relevant molecules, and/or antigens to the host, by administration via a mucosal route such as the intranasal. This invention provides non-replicating vaccine compositions and methods for the delivery of antigens in these vaccine compositions comprising an antigen and a self-adjuvanting carrier, useful for inducing antigen-specific mucosal and systemic immune responses in the host upon immunization via a mucosal route such as intranasal. The vaccine compositions comprise multivalent cations in association with a plurality of spherical archaeal polar lipid aggregates containing aqueous compartments, the AMVAD structure, formed by the interaction of archaeosomes and antigen(s) with multivalent cations such as Ca2+, wherein the AMVAD structure acts as a self-adjuvanting carrier for the antigen(s) in the vaccine composition. Certain advantageous immune responses can also be elicited with the subject compositions.

Cette invention concerne des compositions non répliquantes, ainsi que des méthodes permettant d'administrer ces compositions contenant des produits pharmaceutiques, des molécules à activité biologique et/ou des antigènes à un hôte, par administration par voie muqueuse, telle que par voie intranasale. Cette invention concerne des compositions de vaccins non répliquantes ainsi que des méthodes permettant d'administrer des antigènes dans ces compositions de vaccins comprenant un antigène et un excipient auto-adjuvant, utiles pour induire des réponses immunitaires systémiques et mucosales propres à l'antigène chez l'hôte lors de l'immunisation par voie muqueuse, telle que par voie intranasale. Les compositions de vaccins comprennent des cations polyvalents associés à plusieurs agrégats de lipides polaires d'Archaea sphériques contenant des compartiments aqueux, la structure AMVAD formée par l'interaction d'Archaeosomes et d'un ou de plusieurs antigènes avec des cations polyvalents tels que Ca2+, la structure AMVAD servant d'excipient auto-adjuvant pour le ou les antigènes dans la composition du vaccin. Certaines réponses immunitaires avantageuses peuvent également être induites au moyen de telles compositions.

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