Arg-pro-pro-gly-phe analogs as selective inhibitors of...

Details Arg-pro-pro-gly-phe analogs as selective inhibitors of... Arg-pro-pro-gly-phe analogs as selective inhibitors of...

A - Human Necessities

61

K

A61K 38/08 (2006.01) C07K 7/06 (2006.01) C07K 7/18 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) G01N 33/58 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2524277

The invention relates to compounds and methods for inhibiting human platelet aggregation, thrombosis and cell activation mediated by PAR1 and PAR4 using peptide analogs of Arg-Pro-Pro-Gly-Phe that contain one or more amino acid substitutions. The invention also includes screening methods for identifying compounds that inhibit thrombin mediated activities.

L'invention concerne des composés et des méthodes permettant d'inhiber l'agrégation plaquettaire humaine, la thrombose et l'activation cellulaire induite par des PAR1 et PAR4 à l'aide d'analogues peptidiques de Arg-Pro-Pro-Gly-Phe (SEQ ID NO : 4) qui contiennent au moins une substitution d'acides aminés. L'invention concerne également des méthodes de criblage permettant d'identifier des composés qui inhibent les activités induites par la thrombine.

Affiliated with

Also associated with

Rating

Arg-pro-pro-gly-phe analogs as selective inhibitors of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Arg-pro-pro-gly-phe analogs as selective inhibitors of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Arg-pro-pro-gly-phe analogs as selective inhibitors of... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1720172