C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 5/02 (2006.01) A61K 31/155 (2006.01) A61K 31/69 (2006.01) A61K 49/00 (2006.01)
Patent
CA 2749853
The present invention is directed to arginase inhibitor compounds of formula IA or formula IB: HoN,.Xi,xi H9N,.X1., .chi.{ xz ^z X "x2 ^ z R 1\ R 1 K COOH COOH IA IB or a pharmaceutically acceptable salt thereof, compositions containing these compounds, and methods of their use for the treatment and diagnosis of conditions characterized by upregulation of arginase, abnormally high arginase activity, or by abnormally low nitric oxide synthase activity.
La présente invention concerne des composés inhibiteurs d'arginase de formule IA ou de formule IB : HoN,.Xi,xi H9N,.X1.,?{ xz ^z X "x2 ^z R 1 \ R 1 K COOH COOH IA IB ou l'un de leurs sels de qualité pharmaceutique, les compositions contenant ces composés et leurs méthodes d'utilisation dans le traitement et le diagnostic d'états pathologiques caractérisés par une régulation à la hausse de l'arginase, une activité anormalement élevée de l'arginase ou une activité anormalement faible de l'oxyde nitrique synthétase.
Christianson David W.
Colasanti Andrew Vargha
Olson Gary Lee
Pottorf Richard Scott
Tomczuk Bruce Edward
Arginetix Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Trustees Of The University Of Pennsylvania
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