A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/195 (2006.01) A61K 31/198 (2006.01) A61K 31/223 (2006.01)
Patent
CA 2065040
A method for prophylaxis or treatment of an animal for systemic hypotension induced by internal nitrogen oxide produc- tion. The method involves administering a therapeutically effective amount of certain arginine derivatives to inhibit nitrogen ox- ide formation from arginine. Preferably N G-substituted arginine or an NG,NG- disubstituted arginine (having at least one hy- drogen on a terminal guanidino amino group replaced by another atomic species) is administered to an animal possibly developing or already having such induced systemic hypotension. The arginine derivatives are preferably of the L configura- tion and include pharmaceutically acceptable addition salts. Prophylaxis or treatment of systemic hypotension in a patient which has been induced by chemotherapeutic treatment with biologic response modifiers such as tumor necrosis factor or interleukin-2 may be accomplished. Treatment of an animal for systemic hypotension induced by endotoxin, i.e., septic shock may also be accomplished by treatment with the arginine derivatives.
Griffith Owen W.
Gross Steven S.
Kilbourn Robert G.
Levi Roberto
Lodato Robert F.
Blake Cassels & Graydon Llp
Board Of Regents The University Of Texas System
Cornell Research Foundation Inc.
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