Arginine deiminase conjugate for the treatment of tumours

Details Arginine deiminase conjugate for the treatment of tumours Arginine deiminase conjugate for the treatment of tumours

A - Human Necessities

61

K

A61K 38/50 (2006.01) A61P 35/00 (2006.01) C12N 9/78 (2006.01) C12N 9/96 (2006.01) C12N 11/08 (2006.01)

Patent

CA 2637687

Specific modifying agent is coupled to an anti-tumor protein on a certain site. It conquers the disadvantages which include high antigenicity, short circulating half-life, nonuniform modified sites, inhomogeneous component, reduced activity and uncontrollable quality of the products prepared by non- specific modifying method. The anti-tumor protein coupled with specific modifying agent can be used for the treatment of tumor and for manufacturing an anti-tumor medicament.

Un agent de modification spécifique est couplé à une protéine anti-tumorale sur un certain site. Les désavantages qui s'en suivent sont: une forte anti-génicité, une demi-vie de circulation courte, une non uniformité des sites modifiés, une non homogénéité du composant, une réduction d'activité et une qualité incertaine des produits préparés au moyen du procédé de modification non spécifique. La protéine antitumorale couplée à un agent de modification spécifique sert au traitement des tumeurs et à la préparation d'un médicament antitumoral.

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