Arginine keto-amide enzyme inhibitors

Details Arginine keto-amide enzyme inhibitors Arginine keto-amide enzyme inhibitors

C - Chemistry, Metallurgy

07

K

C07K 5/02 (2006.01) A61K 38/06 (2006.01) C07K 5/06 (2006.01) C07K 5/068 (2006.01) C07K 5/072 (2006.01) C07K 5/078 (2006.01) C07K 5/083 (2006.01) C07K 5/093 (2006.01) C07K 5/113 (2006.01) C07K 14/75 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2146446

The present invention is directed to novel ar- ginine alpha-keto-amide derivatives, their pharma- ceutically acceptable salts and compositions there- of which are useful as antithrombolic agents in mammals and also the use of these compounds as antithrombolic agents. Also, described are meth- ods of using these inhibitors as inhibitors of coagu- lation proteases and as therapeutic agents for dis- ease states characterized by abnormal thrombus formation and/or disorders of the blood coagula- tion process. Further described herein are com- pounds useful as intermediates in the preparation of thesse compounds.

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