Arginine mimic derivatives as enzyme inhibitors

Details Arginine mimic derivatives as enzyme inhibitors Arginine mimic derivatives as enzyme inhibitors

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 38/05 (2006.01)

Patent

CA 2192686

The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.

L'invention concerne des aldéhydes peptidiques qui constituent des inhibiteurs de la thrombine puissants et spécifiques, leurs sels pharmaceutiquement acceptables, des compositions pharmaceutiquement acceptables contenant ces derniers, et leurs méthodes d'utilisation en tant qu'agents thérapeutiques pour les états pathologiques chez les mammifères caractérisés par une thrombose anormale.

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