C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/4515 (2006.01) A61K 31/496 (2006.01) C07D 211/52 (2006.01) C07D 211/52 (2006.01) C07D 403/02 (2006.01)
Patent
CA 2529767
The invention relates to the discovery that pamoate salts of haloperidol and aripiprazole result in a good to superior long acting and/or extended release profile. Thus, in one aspect of the invention, the invention includes pamoate salts of haloperidol or aripiprazole. Preferably, the pamoate salt is characterized by a ratio of haloperidol to pamoate of 1:1 or 2:1. The pamoate salt can be crystalline, such as a needle or a dense crystal, such as described in the Figures. The invention further relates to methods of treating an individual in need thereof comprising administering a pharmaceutical composition comprising a pamoate salt of haloperidol and aripiprazole.
L'invention concerne la découverte du fait que les sels de pamoate d'halopéridol et d'aripiprazole induisent un profil de libération bon à supérieur à long terme et/ou un profil de libération élargi. Ainsi, dans un aspect de l'invention, ladite invention comprend des sels de pamoate d'halopéridol ou d'aripiprazole. De préférence, le sel de pamoate se caractérise par un rapport de l'halopéridol au pamoate de l'ordre de 1 :1 ou de 2 :1. Le sel de pamoate peut être cristallin, comme une aiguille ou un cristal dense, comme décrit dans les figures. L'invention concerne en outre des méthodes de traitement d'individus nécessitant une telle thérapie, qui comprennent l'administration d'une composition pharmaceutique contenant un sel de pamoate d'halopéridol et d'aripiprazole.
Greco Kristyn
Wright James L.
Alkermes Inc.
Alkermes Controlled Therapeutics II
Gowling Lafleur Henderson Llp
LandOfFree
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