Aristeromycin/adenosine derivatives

Details Aristeromycin/adenosine derivatives Aristeromycin/adenosine derivatives

C - Chemistry, Metallurgy

07

D

167/202, 167/211

C07D 473/00 (2006.01) A61K 31/70 (2006.01) C07H 19/052 (2006.01) C07H 19/056 (2006.01) C07H 19/16 (2006.01) C07H 19/167 (2006.01)

Patent

CA 1315779

ABSTRACT This invention relates to an aristeromycin/adenosine derivative of the formula Image wherein V is oxy or methylene, X1 and X2 are each independently hydrogen or halogen with the proviso that at least one of X1 and X2 is always a halogen atom, A1 and A2 are each independently hydrogen, halogen, or hydroxy with the provisos that where A1 is hydroxy, A2 is hydrogen, and that where A2 is hydroxy, A1 is hydrogen, Y1 is nitrogen, a CH group, a CCl group, a CBr group or a CNH2 group, Y2 and Y3 are each independently nitrogen or a CH group, Q is NH2, NHOH, NHCH3, or hydrogen, and Z is hydrogen, halogen, or NH2; or a pharmaceutically acceptable salt thereof, which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.

575389

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