Aromatase-inhibiting composition containing azole derivative

Details Aromatase-inhibiting composition containing azole derivative Aromatase-inhibiting composition containing azole derivative

A - Human Necessities

61

K

A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/4178 (2006.01) A61K 31/4196 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2118443

ABSTRACT OF THE DISCLOSURE The disclosure describes a pharmaceutical composition comprising an aromatase-inhibiting effective amount of a compound selected from the group consisting of compounds of the formula (I): Image (I) including their stereoisomers and salts thereof, wherein R1 is halogen or phenyl; m is 0, 1, 2 or 3; k and n each are independently 0, 1 or 2; R2 and R3 each are independently H or OH; R6 and R7 each are independently H or C1-4 alkyl; R8 and R9 each are H or R8 and R9 form -C(R4)(R5)-C(R11)(R12)- bond wherein R4, R5, R11 and R12 each are independently H or C1-4 alkyl; Y is N or CH; and R10 is H or halogen, or R10 combines with R2 to form -O- bond, with proviso that if R8 and R9 form -C(R4)(R5)- C(R11)(R12)- bond, R3, R6 and R7 each are H, and k and n each are 1, then R2 and R10 form -O- bond, and a pharmaceutically acceptable carrier or diluent.

Affiliated with

Also associated with

Rating

Aromatase-inhibiting composition containing azole derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aromatase-inhibiting composition containing azole derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aromatase-inhibiting composition containing azole derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1352087