Aromatase inhibiting derivatives of substituted 3- or...

Details Aromatase inhibiting derivatives of substituted 3- or... Aromatase inhibiting derivatives of substituted 3- or...

C - Chemistry, Metallurgy

07

D

167/238, 260/280

C07D 231/12 (2006.01) A61K 31/415 (2006.01) C07D 401/06 (2006.01)

Patent

CA 1266665

Abstract of the Disclosure Disclosed are compounds of the formula Image (I) wherein R is 3(5)-pyrazolyl or 4-pyrazolyl; R1 is pyridyl or an optionally substituted phenyl group of the formula Image R2, R3, R4, and R5 are independently hydrogen, halo, C1-C3 alkoxy, or trifluoromethyl; and X is hydrogen, hydroxy, methyl, or halo; provided that when R1 is optionally substituted phenyl, R2, R3, R4, and R5 are not all hydrogen, or a pharmaceutically acceptable salt thereof. These compounds inhibit aromatase and are useful to prevent or treat estrogen-dependent disease.

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