Aromatase inhibitors and monoclonal anti-her2 antibodies as...

Details Aromatase inhibitors and monoclonal anti-her2 antibodies as... Aromatase inhibitors and monoclonal anti-her2 antibodies as...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/4196 (2006.01) A61K 31/5685 (2006.01) A61P 35/00 (2006.01) C07K 16/32 (2006.01)

Patent

CA 2409652

A method of treating a human being suffering from an hormone-dependent disorder characterized by the overexpression of HER2 comprising administering to said human being an aromatase inhibitor e.g. exemestane, fadrozole, letrozole and anastrozole and an antibody against HER2 e.g. trastuzumab, in amounts effective to produce a superadditive or synergistic therapeutic effect.

L'invention concerne un procédé de traitement d'un être humain soufrant d'un désordre hormono-dépendant, caractérisé par une surexpression de HER2, ce procédé consistant à administrer à cet être humain un inhibiteur d'aromatases, par exemple exémestane, fadrozole, létrozole et anastrozole, ainsi qu'un anticorps dirigé contre HER2, par exemple trastuzumab, en doses efficaces pour produire un effet thérapeutique synergique ou superadditif.

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