Aromatic amide compounds and their production and use

Details Aromatic amide compounds and their production and use Aromatic amide compounds and their production and use

C - Chemistry, Metallurgy

07

D

C07D 311/06 (2006.01) A61K 31/165 (2006.01) A61K 31/365 (2006.01) C07C 235/38 (2006.01) C07C 235/78 (2006.01) C07D 311/12 (2006.01) C07D 311/14 (2006.01) C07D 311/20 (2006.01)

Patent

CA 2068636

ABSTRACT Aromatic amide compounds of the formula: Image (I) wherein R1, R2, and R3 are independently hydrogen, a lower alkyl or lower alkoxy group; Ar is an optionally substituted aromatic group; the group Image is C= C or HC-CH; X is hydrogen, CH2COOH or CH2CONHAr; and Y is hydrogen or COOH; provided that when X is CH2COOH or Y is COOH, the COOH may be taken together with the adjacent hydroxy group on the benzene ring to form a lactone ring by dehydration, a quinone form thereof or a pharmaceutically acceptable salt thereof have potent nerve growth factor (NGF) secretion inducing activity, and are thus useful as a drug for the treatment or prophylaxis of degenerative nervous system disorders such as senilic dementis, and Alzheimer's disease.

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