Aromatic amide derivatives, medicinal compositions...

C - Chemistry – Metallurgy – 07 – D

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C07D 243/14 (2006.01) A61K 31/5513 (2006.01) A61P 13/02 (2006.01) A61P 43/00 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 407/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2588768

Aromatic amide derivatives represented by the general formula (I) which have V2 receptor stimulating activity and are useful as preventive or therapeutic agents for diabetes insipidus, night pollakisuria, night enuresis, overactive bladder, and so on; pharmacologically acceptable salts thereof; prodrugs of both, medicinal compositions containing them; and medical uses thereof: (I) wherein R1 is hydrogen or optionally substituted C1-6 alkyl; R2 is hydrogen or C1-6 alkyl; R3 is hydrogen, C1-6 alkyl, or the like; R4, R5 and R6 are each independently hydrogen, halogeno, or the like; R7 is hydrogen, optionally substituted heteroaryl, C3-8 cycloalkyl, optionally substituted amino, or optionally substituted alkoxy; M1 is a single bond, C1-4 alkylene, or the like; and Y is N or CRF (wherein RF is hydrogen, C1-6 alkyl, or the like).

L'invention concerne des dérivés d~amides aromatiques représentés par la formule générale (I) dont l~activité stimule les récepteurs V2 et qui sont utiles en tant qu~agents préventifs ou thérapeutiques pour le diabète insipide, la pollakiurie nocturne, l~énurésie nocturne, la vessie hyperactive etc. ; des sels pharmacologiquement acceptables de ceux-ci ; des promédicaments de ces deux éléments, des compositions médicinales contenant ceux-ci ainsi que les usages médicaux de ceux-ci : (I) dans laquelle R1 est hydrogène ou alkyle facultativement substitué en C1-6 ; R2 est hydrogène ou alkyle en C1-6 ; R3 est hydrogène, alkyle en C1-6 ou éléments similaires; R4, R5 et R6 sont chacun indépendamment hydrogène, halogéno, ou éléments similaires ; R7 est hydrogène, hétéroaryle facultativement substitué, cycloalkyle en C3-8, amino facultativement substitué ou alkoxy facultativement substitué ; M1 est une simple liaison, alkylène en C1-4 ou éléments similaires ; et Y est N ou CRF (dans laquelle RF est hydrogène, alkyle en C1-6, ou éléments similaires).

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