C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) C07D 205/04 (2006.01) C07D 207/08 (2006.01) C07D 207/09 (2006.01) C07D 207/10 (2006.01) C07D 211/34 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 409/06 (2006.01) C07D 409/14 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2256438
The present invention relates to a novel thrombin inhibitor which is effective even when orally administered. More specifically, the present invention relates to an aromatic amidine derivative represented by formula (I) and the salts thereof, which show potent selective inhibitory activity for thrombin in which (a), R, R1, R2, R3, A, W, Y and n are defined as described in the specification.
L'invention concerne un nouvel inhibiteur de la thrombine qui est efficace même lorsqu'il est administré par voie orale. Plus spécifiquement, l'invention concerne un dérivé d'amidine aromatique représenté par la formule (I) et des sels de celle-ci, qui présentent une activité inhibitrice sélective pour la thrombine. Dans ladite formule, (a), R, R?1¿, R?2¿, R?3¿ A, W, Y et n sont définis comme décrits dans la spécification.
Hong Woo Sang
Kim Jong Min
Koo Bon Am
Min Jae Ki
Nam Woong Hyun
C. & C. Research Laboratories
Robic
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