C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/278
C07D 211/34 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) C07D 211/14 (2006.01) C07D 211/16 (2006.01) C07D 211/18 (2006.01) C07D 211/22 (2006.01) C07D 211/28 (2006.01) C07D 211/32 (2006.01) C07D 211/70 (2006.01) C07D 295/13 (2006.01) C07D 295/15 (2006.01) C07D 295/192 (2006.01) C07D 317/58 (2006.01) C07D 317/60 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2029275
IN THE UNITED STATES PATENT AND TRADEMARK OFFICE PATENT APPLICATION entitled: Aromatic amine compounds, their method of preparation and pharmaceutical compositions in which they are present in the names of: Xavier EMONDS-ALT Pierre GOULAOUIC Vincenzo PROIETTO Didier VAN BROECK Assignee: SANOFI ABSTRACT OF THE DISCLOSURE The invention relates to compounds of the formula Image (I) in which: - m is an integer from 1 to 3; - Ar and Ar' independently are a thienyl group; a substituted or unsubstituted phenyl group; or an imidazolyl group; it also being possible for Ar- to be a benzothienyl group which is unsubstituted or substituted by a halogen; a naphthyl group which is unsubstituted or substituted by a halogen; a biphenyl group; or a substituted or unsubstituted indolyl; - X is hydrogen; - X' is hydrogen or a hydroxyl group or is joined to X" below to form a carbon-carbon bond, ? or X and X' together form an oxo group or a di- alkylaminoalkoxyimino group of the formula =N-O-(CHz)p-Am, in which p is 2 or 3 and Am is a dialkylamino group; - Y is a nitrogen atom or a group C(X"), in which X" is hydrogen or forms a carbon-carbon bond with X'; - Q is hydrogen, a C1-C4 alkyl group or an aminoalkyl group of the formula -(CH2)q-Am', in which q is 2 or 3 and Am' is a piperidino, 4-benzylpiperidino or dialkylamino group; R is hydrogen, a methyl group or a group (CH2)n-L, in which n is an integer from 2 to 6 and L is hydrogen or an amino group; _ T is a group selected from Image and Image W being an oxygen or sulfur atom; and - Z is either hydrogen, or M or OM when T is the group -C(=O)-, or M when T is the group -C(=W)-NH-, M being hydrogen; a linear or branched alkyl; a substituted or unsubstituted phenylalkyl; a pyridylalkyl; a naphthylalkyl; a pyridylthioalkyl; a styryl; a 1- methylimidazol-2-ylthioalkyl; a 1-oxophenyl-3-indan- 2-yl; or a substituted or unsubstituted aromatic or heteroaromatic group; or to one of their salts with mineral or organic acids. Application: neurokinin receptor antagonists.
Emonds-Alt Xavier
Goulaouic Pierre
Proietto Vincenzo
Van Broeck Didier
Sanofi
Sim & Mcburney
LandOfFree
Aromatic amine compounds, their method of preparation and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aromatic amine compounds, their method of preparation and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aromatic amine compounds, their method of preparation and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1695634