Aromatic amine derivatives as pharmaceutical agents

Details Aromatic amine derivatives as pharmaceutical agents Aromatic amine derivatives as pharmaceutical agents

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/44 (2006.01) C07D 207/16 (2006.01) C07D 213/82 (2006.01)

Patent

CA 2331791

Aromatic amines of formula (1) are described: wherein Az is an optionally substituted monocyclic six-membered nitrogen-containing aromatic group; L1 is a linker atom or group; R is a carboxylic acid or a derivative thereof; and R5 is a group -L2(CH2)tR6 in which L2 is a -N(R7)CO- or -N(R7)CS- group. The compounds are able to inhibit the binding of .alpha.4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.

L'invention concerne des amines aromatiques de la formule (1) dans laquelle : Az représente un groupe aromatique éventuellement substitué, monocyclique, à six éléments et contenant de l'azote; L?1¿ représente un atome ou un groupe de liaison; R représente un acide carboxylique ou son dérivé; et R?5¿ représente un groupe -L?2¿(CH¿2?)¿t?R?6¿ dans lequel L?2¿ est un groupe -N(R?7¿)CO- ou -N(R?7¿)CS-. Les composés selon l'invention sont capables d'inhiber la liaison d'intégrines .alpha.¿4? avec leurs ligands et s'utilisent dans la prophylaxie et le traitement de troubles immunitaires ou inflammatoires.

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