Aromatic amine derivatives having nos inhibiting action

Details Aromatic amine derivatives having nos inhibiting action Aromatic amine derivatives having nos inhibiting action

C - Chemistry, Metallurgy

07

C

C07C 211/54 (2006.01) A61K 31/135 (2006.01) A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/505 (2006.01) C07C 209/10 (2006.01) C07C 211/56 (2006.01) C07C 217/92 (2006.01) C07C 271/20 (2006.01) C07D 203/12 (2006.01) C07D 205/04 (2006.01) C07D 207/335 (2006.01) C07D 207/337 (2006.01) C07D 213/74 (2006.01) C07D 213/76 (2006.01) C07D 213/80 (2006.01) C07D 213/81 (2006.01) C07D 213/82 (2006.01) C07D 21

Patent

CA 2275933

Compounds represented by general formula (1) which have NOS inhibitory activities and are useful as drugs, for example, remedies for cerebrovascular disorders, wherein R1 and R2 represent each hydrogen, etc.; R3 and R4 represent each hydrogen, lower alkyl, etc.; R5 represents hydrogen, etc.; X1, X2, X3 and X4 represent each hydrogen, lower alkoxyl, etc.; A represents an optionally substituted pyridine ring, etc.; and m and n are each 0 or 1.

Cette invention concerne des composés correspondant à la formule générale (1) où R¿1? et R¿2? représentent chacun hydrogène, entre autres. R¿3? et R¿4? représentent chacun hydrogène, alkyle inférieur, etc., tandis que R¿5? représente hydrogène, entre autres. X¿1?, X¿2?, X¿3? et X¿4? représentent chacun hydrogène, alcoxy inférieur, etc., tandis que A représente entre autres un anneau pyridine éventuellement substitué, et que n et m sont chacun égaux à 0 ou 1. Ces composés ont une action inhibitrice à l'égard des NOS, et peuvent être utilisés comme médicaments et, par exemple, comme remèdes dans le cas de troubles cérébrovasculaires.

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