Aromatic amino-alcohol derivatives having anti-diabetic and...

Details Aromatic amino-alcohol derivatives having anti-diabetic and... Aromatic amino-alcohol derivatives having anti-diabetic and...

C - Chemistry, Metallurgy

07

C

C07C 229/34 (2006.01) A61K 31/135 (2006.01) A61K 31/165 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/425 (2006.01) C07C 217/18 (2006.01) C07C 217/70 (2006.01) C07C 235/34 (2006.01) C07C 237/20 (2006.01) C07C 239/08 (2006.01) C07C 255/59 (2006.01) C07C 259/06 (2006.01) C07C 323/25 (2006.01) C07C 323/62 (2006.01) C07C 323/63 (2006.01) C07D 277/20 (2006.01) C07D 277/34 (2006.01)

Patent

CA 2083323

1886 ABSTRACT OF THE DISCLOSURE Compounds of formula (I): Image (I) (wherein: RO is hydrogen, methyl or hydroxymethyl; R1 is substituted alkyl; R2 and R3 are each hydrogen, halogen, hydroxy, alkoxy, carboxy, alkoxycarbonyl, alkyl, nitro, haloalkyl, or substituted alkyl; X is oxygen or sulfur; and Ar optionally substituted phenyl or naphthyl); and pharmaceutically acceptable salts thereof have a variety of valuable pharmaceutical activities, including anti-diabetic and anti-obesity activities; in addition, they are capable of treating or preventing hyperlipemia and hyperglycemia and, by inhibiting the action of aldose reductase, they can also be effective in the treatment and prevention of complications of diabetes.

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