C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/295, 260/291
C07D 309/12 (2006.01) C07C 203/04 (2006.01) C07D 213/64 (2006.01) C07D 213/69 (2006.01) C07D 303/24 (2006.01) C07D 303/26 (2006.01)
Patent
CA 1157474
Abstract of the Disclosure Compounds represented by the following formula Image (I) wherein A represents a direct bond or the bond -O-CH2-, B represents a C1-C11 alkylene group bonded to a carbon atom of the aro- matic ring D either directly or through -O-, -S, -SO- or -NH-, W represents a carbon or nitrogen atom, R1 represents a C3-C7 alkyl group, a hydroxy-C1-C6 alkyl group, or a phenyl- or diphenyl-alkyl group with the alkyl group having 1 to 4 carbon atoms, R2 represents a member selected from the group consisting of hydrogen, halogen, OH, C1-C4 alkyl, NO2, C1-C4 alkoxy, acetyl, allyloxy, carbamoyl and sulfamoyl, and when two or more R2 groups exist, they may be identi- cal or different, and n represents 1, 2 or 3 and m represents 1 or 2, provided that n + m ? 4; and acid addition salts thereof are disclosed as well as processes for producing them and pharmaceutical compositions containing the aforesaid compounds. The compounds (I) exhibit muscle relaxing and adrenergic blocking action, as well as myocardial oxygen consumption lowering action and blood pressure lowering action.
370754
Akashi Toshihiro
Kawamura Kiyoshi
Kunieda Hisashi
Kyotani Yoshinori
Nagakura Masahiko
Kowa Company Ltd.
Smart & Biggar
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