C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/309
C07D 277/82 (2006.01) A61K 31/425 (2006.01) C07D 417/12 (2006.01)
Patent
CA 1328871
ABSTRACT OF THE DISCLOSURE Acyl derivatives of 2-aminobenzothiazole and alkylated analogs of the formula: Image ---I ---II ---III or Image ---IV (wherein X is alkyl, hydrogen, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, nitro, trifluoromethyl, carbamyl, N,N-dialkylcarbamyl, phenyl, fluorophenyl, methoxy- phenyl, hydroxyphenyl, cyano, cyclohexyl or hydroxy- alkyl; Y is hydrogen, alkyl, alkoxy, F or C1; W is hydrogen, alkoxy, cyano, F, C1 or Br; X and Y together may form a benzo or tetrahydro- benzo ring; Z is hydrogen, F, C1, Br or alkyl; R is a substituent of the formula: Image -(Q)-(CH2)pNR4R5 [where n is an integer of 0 to 2; m is an integer of 0 to 1; R3, R4 and R5 are each hydrgoen alkyl; Q is CH2, O, NR4 or S; p is an integer of 2 to 3; R4 and R5 together with the nitrogen may form a saturated heterocyclic] R1 is hydrogen or methyl; R2 is hydrogen, alkyl, nitro, cyano, trifluoromethyl, F, C1 or Br; and R6 is alkyl, alkoxycarbonylmethyl, with the proviso that in formula I, R is at the m- or p-position to the carbonyl and p is 2 or 3 when Q is O, NR4 or S) are use- ful as antitumor agents and anti-plasmin agents.
600370
Fliri Anton Franz Josef
Schnur Rodney Caughren
Pfizer Inc.
Smart & Biggar
LandOfFree
Aromatic and heterocyclic carboxamide derivatives as... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Aromatic and heterocyclic carboxamide derivatives as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aromatic and heterocyclic carboxamide derivatives as... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1242823