Aromatic and heterocyclic thiazolyl thiourea compounds and use

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 277/48 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61P 31/18 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2426148

Novel aromatic and heterocyclic thiazolyl thiourea compounds, of the formula I and II and pharmaceutical compositions including such, and methods for their use are disclosed. The compounds are effective agents for the treatment of HIV infection, including non-nucleoside inhibitor-resistant, and multi-drug resistant strains of HIV.

La présente invention concerne de nouveaux composés de thiazolyl thiourée aromatiques et hétérocycliques, de la formule I et II et des compositions pharmaceutiques les contenant, ainsi que des méthodes d'utilisation desdits composés. Lesdits composés sont des agents efficaces pour le traitement des infections à VIH, notamment des souches de VIH résistantes aux inhibiteurs non nucléotidiques et à l'action de plusieurs médiacaments.

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