C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 405/00 (2006.01)
Patent
CA 2303764
The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to formula (A), wherein R1, R2, R3, R4, X, Y and Z are defined below. This invention also includes optical isomers, diastereomers and enantiomers of said formula, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. The compounds of the present invention are useful for the treatment of a variety of diseases and conditions, such as bone disorders and glaucoma. Accordingly, the invention further provides pharmaceutical compositions comprising these compounds. The invention still further provides methods of treatment for bone disorders and glaucoma using these compounds or the compositions containing them.
Cette invention porte sur de nouveaux analogues de PGF (prostaglandine F), et notamment sur de nouveaux composés ayant une structure selon la formule (A) dans laquelle R1, R2, R3, R4, X, Y et Z sont tels que définis ci-après. Cette invention comprend également des isomères optiques, des diastéréomères et des énantiomères de la formule (A), et des sels pharmaceutiquement acceptables, des amides biohydrolysables, des esters et des imides de ceux-ci. Les composés de la présente invention sont utiles dans le traitement de divers états et pathologies tels que les maladies osseuses et le glaucome. L'invention porte également sur des compositions pharmaceutiques comprenant ces composés, ainsi que sur des procédés de traitement des maladies osseuses et du glaucome à l'aide de ces composés ou des compositions les contenant.
Amburgey Jack S. Jr.
Dai Haiyan George
De Biswanath
Delong Mitchell Anthony
Wang Yili
Duke University
Kirby Eades Gale Baker
The Procter & Gamble Company
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