C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/06 (2006.01) A61K 31/16 (2006.01) A61K 31/21 (2006.01) A61K 31/275 (2006.01) A61K 31/505 (2006.01) C07C 211/29 (2006.01) C07C 217/48 (2006.01) C07C 217/64 (2006.01) C07C 229/10 (2006.01) C07C 229/14 (2006.01) C07C 229/36 (2006.01) C07C 233/18 (2006.01) C07C 233/22 (2006.01) C07C 233/73 (2006.01) C07C 237/08 (2006.01) C07C 237/20 (2006.01) C07C 251/48 (2006.01) C07C 255/13 (2006.01) C07C 255/24 (2006.01) C07C 255/25 (2006.01) C07C 255/54 (2006.01) C07C 271/16 (2006.01) C07C 271/20 (2006.01) C07C 271
Patent
CA 2110725
2110725 9301165 PCTABS00019 Compounds of formula (I) and salts and prodrugs thereof wherein, Q is optionally substituted phenyl, heteroaryl or naphthyl; X and Y are each H, C1-6 alkyl, C2-6 alkenyl or X and Y are together =O; Z is O or S; R1 is H, optionally substituted C1-6 alkyl, optionally substituted phenyl(C1-4 alkyl), C2-6 alkylene, COC1-6 alkylhalo, CORa, COORa, CONHRa, COC1-6alkylNRaRb or CONRaC1-6alkylCONRaRb; R2 is substituted C1-6 alkyl, optionally substituted phenyl(C1-4 alkyl), C2-6 alkylene, C1-6alkylhalo, CORa, COORa, CONHRa, COC1-6alkylNRaRb or CONRaC1-6alkylCONRaRb; or R1 and R2 together form a chain (CH2)p optionally substituted by oxo; R3 is H or C1-6 alkyl; R4 is H, C1-6 alkyl or phenyl; and R5 is optionally substituted (CH2)qphenyl; are tachykinin antagonists useful for treating pain.
Owens Andrew P.
Williams Brian J.
Merck Sharp & Dohme Limited
Swabey Ogilvy Renault
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