Aromatic compounds having cyclic amino or salts thereof

Details Aromatic compounds having cyclic amino or salts thereof Aromatic compounds having cyclic amino or salts thereof

C - Chemistry, Metallurgy

07

D

C07D 211/26 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2318351

Compounds represented by general formula (I) or salts thereof which specifically inhibit FXa, exert a potent anticoagulant effect and thus are useful as medicinal compositions, wherein G1 to G4, X and Y represent each CH or N; Z1 represents -SO2- or -CH2-; Q represents aryl or heteroaryl; and R1 to R9 represent each hydrogen or a substituent.

L'invention concerne des composés représentés par la formule générale (I) ou leurs sels, qui inhibent de façon spécifique FXa, exercent un puissant effet anticoagulant et s'utilisent par conséquent comme compositions médicamenteuses. Dans la formule (I), G¿1? à G¿4?, X et X représentent chacun CH ou N; Z¿1? représente -SO¿2?- ou -CH¿2?-; Q représente aryle ou hétéroaryle; et R¿1? à R¿9? représentent chacun hydrogène ou un substituant.

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