Aromatic compounds, pharmaceutical compositions containing...

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C - Chemistry, Metallurgy

07

C

C07C 217/48 (2006.01) A61K 31/00 (2006.01) C07C 211/29 (2006.01) C07C 217/64 (2006.01) C07C 229/14 (2006.01) C07C 229/36 (2006.01) C07C 233/18 (2006.01) C07C 233/22 (2006.01) C07C 233/73 (2006.01) C07C 237/06 (2006.01) C07C 237/08 (2006.01) C07C 237/20 (2006.01) C07C 255/13 (2006.01) C07C 255/54 (2006.01) C07C 255/59 (2006.01) C07C 271/16 (2006.01) C07C 271/20 (2006.01) C07C 271/22 (2006.01) C07C 275/10 (2006.01) C07C 275/24 (2006.01) C07C 275/28 (2006.01) C07C 275/32 (2006.01) C07C 311/04 (2006.01) C07D 20

Patent

CA 2110513

2110513 9301160 PCTABS00019 Compounds of formula (I), and salts and prodrugs thereof, wherein Q is R9CR10R11 or CH2R9CR10R11 where R9 is H or OH and R10 and R11 are optionally substituted phenyl, optionally substituted benzyl, C5-7cycloalkyl or (C5-7cycloalkyl)methyl; R1 and R2 are H, optionally substituted C1-6 alkyl, optionally substituted phenyl(C1-4 alkyl), C2-6 alkenyl, C2-6 alkynyl, CORa, COORa, COC1-6alkylhalo, COC1-6alkylNRaRb, CONR12C1-6alkylCONRaRb, CONRaRb, or SO2Ra, or R1 and R2 together form a chain (CH2)q optionally substituted by oxo where one methylene group may optionally be replaced by O or NRx; R3 is H, C1-6 alkyl or C2-6alkenyl; R4 is optionally substituted phenyl(C1-3 alkyl); X and Y are H, or X and Y together are =O; and Z is O, S, or NR7; are tachykinin antagonists. They and compositions thereof are useful in therapy.

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