Aromatic compounds, pharmaceutical compositions containing...

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C - Chemistry, Metallurgy

07

D

C07D 209/10 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) A61K 31/215 (2006.01) A61K 31/33 (2006.01) C07C 211/29 (2006.01) C07C 217/48 (2006.01) C07C 217/64 (2006.01) C07C 229/14 (2006.01) C07C 229/34 (2006.01) C07C 229/36 (2006.01) C07C 233/18 (2006.01) C07C 233/22 (2006.01) C07C 233/47 (2006.01) C07C 233/73 (2006.01) C07C 237/06 (2006.01) C07C 237/08 (2006.01) C07C 237/20 (2006.01) C07C 255/13 (2006.01) C07C 255/54 (2006.01) C07C 271/16 (2006.01) C07C 271/20 (2006.01) C07C 271/22 (2006.01) C07C 275

Patent

CA 2110514

2110514 9301169 PCTABS00019 Compounds of formula (I), and salts and prodrugs thereof, wherein Q represents optionally substituted phenyl, naphthyl, indolyl, benzothiophenyl, benzofuranyl, benzyl or indazolyl; Z represents O, S or NR8; X and Y are H or are together =O; R1 and R2 are H; optionally substituted C1-6alkyl; optionally substituted phenyl(C1-4alkyl); CORc; CO2Rc; CONRcRd; CONRcCOORd; or SO2Rc; R3 is H or C1-6alkyl, R4 is H, C1-6alkyl or optionally substituted phenyl; and R5 represents optionally substituted phenyl; are tachykinin antagonists. They and compositions thereof are useful in therapy.

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