Aromatic derivative and preparation method thereof

Details Aromatic derivative and preparation method thereof Aromatic derivative and preparation method thereof

C - Chemistry, Metallurgy

07

C

260/472.3, 260/4

C07C 69/618 (2006.01) C07C 33/38 (2006.01) C07C 233/55 (2006.01) C07D 333/24 (2006.01)

Patent

CA 1285573

AROMATIC DERIVATIVE AND PREPARATION METHOD THEREOF ABSTRACT OF THE DISCLOSURE An aromatic derivative having the formula (I) or the salt thereof: Image (I) wherein R1 and R2 independently represent a hydrogen atom, hydroxyl, a halogen atom, or OR3 wherein R3 is C1-C10 alkyl; A-B represents a hydrocarbon moiety having 1 to 10 carbon atoms and containing at least one double bond or a sulfur- or oxygen-containing hydrocarbon moiety having 1 to 10 carbon atoms; n is an integer of 2 to 4; X represents a group -?-O, -O-, -O-?-, or -?-NH- and Y represents a hydrogen atom; alkyl having 1 to 5 carbon atoms which may be substituted with aryl; alkenyl having 2 to 5 carbon atoms which may be substituted with aryl or aryl suhstituted with at least one C1-C5 alkoxy; aryl which may be substituted with at least one carboxy or C1-C5 alkoxycarbonyl or C1-C5 alkoxy; provided that, when R1 and R2 are both hydrogen, the moiety -A-B-(CH2)n-X-Y does not represent -CH=CH ?(CH2)n COOR wherein n = 2 to 4 and R4 is hydrogen or C1-C5 alkyl. These pharmaceutical products are useful for the treatment of diseases caused by arachidonic acid cascade metabolic products.

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