Aromatic di-acid-containing poly (ester amide) polymers and...

C - Chemistry – Metallurgy – 08 – L

Patent

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Details

C08L 77/12 (2006.01) A61K 47/48 (2006.01) A61L 17/10 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2667944

The present invention provides biodegradable, biocompatible aromatic di-acid- containing poly(ester amide) (PEA) polymers with thermo-mechanical properties that can be readily tailored by selection of various combinations and proportions of the di-acid residues in the polymers. The polymers are suitable for use in production of drug-releasing biodegradable particles and implantable surgical devices, such as stents and internal fixation devices. The polymer compositions and surgical devices biodegrade in vivo by enzymatic action to release bioactive agents in a controlled manner over time as well as biocompatible breakdown products, including one to multiple different amino acids.

La présente invention concerne des polymères de polyester amide (PEA) biodégradables contenant un diacide aromatique biocompatible. Ces polymères présentent des propriétés thermomécaniques qui peuvent facilement être adaptées en sélectionnant diverses combinaisons et proportions des résidus de diacide dans les polymères. Lesdits polymères sont conçus pour être utilisés dans la production de particules biodégradables à libération de médicament et de dispositifs chirurgicaux implantables, tels que des endoprothèses et des dispositifs de fixation interne. Les compositions de polymère et les dispositifs chirurgicaux se biodégradent in vivo par action enzymatique afin de libérer des agents bioréactifs de manière contrôlée dans le temps, ainsi que des produits de dégradation biocompatibles, y compris un à plusieurs acides aminés différents.

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