Aromatic heterocyclic derivatives as enzyme inhibitors

Details Aromatic heterocyclic derivatives as enzyme inhibitors Aromatic heterocyclic derivatives as enzyme inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/76 (2006.01) C07D 211/56 (2006.01) C07D 211/76 (2006.01) C07D 213/75 (2006.01) C07D 239/46 (2006.01) C07D 239/47 (2006.01) C07D 239/545 (2006.01) C07D 401/00 (2006.01) C07D 401/12 (2006.01) C07D 403/02 (2006.01) C07D 405/02 (2006.01) C07D 409/02 (2006.01) C07F 9/547 (2006.01) C07K 5/06 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2206400

The present invention discloses peptide aldehydes of formula (I) which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof, and methods of using them as therapeutic agents for disease states in mammals characterized by abnormal thrombosis.

La présente invention concerne des aldéhydes peptidiques ayant la formule (I) utilisables comme inhibiteurs puissants et spécifiques de la thrombine, leurs sels pharmaceutiquement acceptables et les compositions pharmaceutiquement acceptables de ces produits, ainsi que les méthodes permettant d'employer de tels inhibiteurs comme agents thérapeutiques pour soigner chez les mammifères les états pathologiques caractérisés par une thrombose anormale.

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